[Immunoglobulins and hyperlipoproteinemias]

With the objective of detecting autoimmune hyperlipidemias (AIH) we looked for the immunoglobulins bound to the low-density lipoproteins (test Ig-Lp): in 50 normolipidemic subjects and, in 133 hyperlipoproteinemic patients: 43 of type IIa, 34 of type IIb, 36 of type IV and 20 of Type V. The Ig-Lp was negative in the 50 normolipidemic subjects. It was positive in 26 hyperlipoproteinemic cases, including; 5 of type IIA, 3 of type IIb, 7 of type IV and 11 of type V. These results were compared to those of a previous smaller study, which had not been randomized. The present work confirms the interest of such a test. Although it does not allow to ascertain that the tested hyperlipoproteinemias are AIH, it suggests that there is a specific relation between immunoglobulins and lipoproteins.