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Saccadic system plasticity in humans

L A Abel, D Schmidt, L F Dell'Osso

    Annals of Neurology
    |October 1, 1978
    PubMed
    Summary
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    This study shows the adult human brain can adapt eye movement control. Patching one eye altered saccadic eye movements, demonstrating neural plasticity in the central nervous system.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Systems Neuroscience

    Background:

    • Third nerve palsy can cause medial rectus paresis, affecting eye movement.
    • Understanding the adaptability of saccadic eye movements is crucial for neurological and visual rehabilitation.

    Observation:

    • A subject with partial third nerve palsy and medial rectus paresis underwent a patching protocol.
    • Saccadic eye movements were measured daily, with patching alternating between the paretic and unaffected eye.

    Findings:

    • Patching the unaffected eye increased saccadic gain, while patching the paretic eye decreased it, indicating adaptive changes.
    • These adaptations occurred with specific time constants, suggesting distinct neural mechanisms for gain increase and decrease.
    • Analysis indicated that gain changes were primarily mediated by alterations in the pulse width of neural activity, not firing frequency.

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    Implications:

    • The findings demonstrate significant central nervous system plasticity in adult humans regarding saccadic eye movement generation.
    • This highlights the potential for therapeutic interventions targeting neural plasticity to improve visual function after nerve palsy or other visual impairments.