Immunological consequences of vasectomy

In more than 50% of men, vasectomy leads to auto-immune pathology. The auto-immune response to sperms following vasectomy is triggered by the phagocytosis of sperm in the epididymis. In the humoral immune response, sperm agglutinating, sperm immobilizing, and antibodies to sperm nuclear protamines occur, as early as 3-4 days after vasectomy. The incidence reaches 60-70% within 1 year and remains almost the same even after 20 years. Presence and effects of circulating immune complexes following vasectomy are discussed with reference to reported increased incidence of atherosclerosis and auto-immune orchitis in experimental animals. There is no positive conclusion whether vasectomy leads to cell mediated immunity to spermatozoa.