[Experimental study of the changes in a previously damaged and normal myocardium under the influence of hemorrhagic...

The authors examined morphologic changes in preliminarily damaged and normal myocardium under the influence of hemorrhagic shock. It was established that the preceding damages of the myocardium (microcicatrixes and organizing microinfarctions) made it more sensitive to acute hypoxia under the conditions of hemorrhagic shock. The electrone microscopic and histologic findings in both groups revealed acute and ischemic damages of the myocardium, manifested in vacuolization and distruction of mitochondria, dilatation of sarcoplasmic reticulum, contracted changes and fuxinophilic necrosis. The morfometric determination of the degree of distribution of fuxinophilic necrosis revealed that they were considerably more manifested under the conditions of hemorrhagic shock on the background of myocardiopathy (p less than 0.001).