Effect of indoramin on finger blood flow in vasospastic patients

The effect of indoramin on blood pressure, heart rate and finger blood flow was investigated in eleven patients with essential acrocyanosis. Indoramin 50 mg t.i.d. and placebo were administered for 6 weeks, in random order in a double blind, cross-over trial. In 8 of the 11 patients, finger blood flow, measured by venous occlusion plethysmography was higher and resistance was lower with indoramin. There was no significant change in blood pressure or heart rate. Thus, indoramin may be useful when a decrease in alpha-adrenoreceptor tone in the fingers is desirable.