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Updated: Aug 9, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Heparin cofactor activity during and after extracorporeal circulation with bubble and membrane oxygenators
Abstract:
Heparin cofactor activity as measured by an amidolytic method has been investigated in 48 patients undergoing cardiac surgery with extra-corporeal circulation (E.C.C.). Heparin cofactor activity is reduced soon after the start of E.C.C., due to hemodilution but it returns towards initial levels at the completion of the procedure and 3 hours later. Thus heparin cofactor does not seem to play a role in the heparin rebound phenomenon. In our patients bubble oxygenators did not modify heparin cofactor activity more than did membrane oxygenators.
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