Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multi-flash campimetry in multiple sclerosis

E M Brussell, C W White, M Bross

    Current Eye Research
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Beyond prediction intervals in meta-analysis: reporting the expected proportion of comparable studies with clinically relevant benefit or harm.

    BMC medical research methodology·2025
    Same author

    Avoidance of Profound Hypothermia During Initial Reperfusion Improves the Functional Recovery of Hearts Donated After Circulatory Death.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    Physiologic Changes in the Heart Following Cessation of Mechanical Ventilation in a Porcine Model of Donation After Circulatory Death: Implications for Cardiac Transplantation.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    Variables Associated with Severity of Bacterial Canker and Wilt Caused by Clavibacter michiganensis subsp. michiganensis in Tomato Greenhouses.

    Phytopathology·2015
    Same author

    Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH).

    British journal of pharmacology·2011
    Same author

    Physiologic assessment of coronary artery stenosis severity.

    Trends in cardiovascular medicine·2011
    Same journal

    Apolipoprotein C3 Promotes Retinal Angiogenesis via the MYC Pathway in Hypoxia.

    Current eye research·2026
    Same journal

    Possible Causal Association Between Thyroid-Related Traits and Diabetic Retinopathy Risk: Evidence From 23 Medication-Taking Traits.

    Current eye research·2026
    Same journal

    Linking Microstructure to Mechanics in ICG-Stained Lens Capsules: Insights from Nanoindentation to Electron Microscopy.

    Current eye research·2026
    Same journal

    Corneal Sensitivity, Sub-Basal Corneal Nerve Plexus, and Tear Neuropeptides in Symptomatic Versus Asymptomatic Visual Display Terminal Users.

    Current eye research·2026
    Same journal

    Selective Laser Trabeculoplasty Mitigates Dexamethasone-Induced Myofibroblast-Like Transformation and Dysfunction in Human Trabecular Meshwork Cells.

    Current eye research·2026
    Same journal

    Usefulness of the Entropy of the Bayesian Posterior Distribution of the Threshold to Assess the Reliability of Measured Visual Field.

    Current eye research·2026
    See all related articles

    This study introduces a new psychophysical test to measure temporal resolution across the visual field. The technique reveals normal visual field patterns in controls and identifies specific areas of reduced temporal resolution in multiple sclerosis patients.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Psychophysics

    Background:

    • Assessing visual function is crucial for diagnosing neurological disorders.
    • Temporal resolution, the ability to perceive rapid changes in light, is a key aspect of visual function.
    • Existing methods for measuring temporal resolution can be time-consuming and lack detailed spatial mapping.

    Purpose of the Study:

    • To develop and validate a novel psychophysical technique for assessing temporal resolution.
    • To map temporal resolution across 120 retinal locations per eye.
    • To evaluate the technique's utility in identifying visual field deficits in multiple sclerosis (MS) patients.

    Main Methods:

    • A computer-generated visual stimulus was used, presenting a small spot of light modulated at 5 Hz.

    Related Experiment Videos

  • The 'off' period of the light stimulus was systematically increased until participants perceived flickering.
  • Data were collected from control observers and individuals with multiple sclerosis.

    • Main Results:

    • Control observers demonstrated good temporal resolution in the central visual field, with a decline in peripheral regions.
    • Multiple sclerosis patients exhibited "islands" of significantly reduced temporal resolution.
    • These deficits in MS patients are hypothesized to correlate with demyelination in the optic nerve.

    Conclusions:

    • The developed psychophysical technique provides a rapid and spatially detailed assessment of temporal visual resolution.
    • The method effectively identifies localized visual field impairments characteristic of multiple sclerosis.
    • This technique holds promise for early detection and monitoring of visual pathway damage in neurological conditions.