[Mitotic regime study in the morphological diagnosis of tumors]

Studies on the mitotic regimen (MR) have shown that common and atypical hyperplasia, dysplasia and tumours which develop in the epithelial tissues in connection with disturbances in cell division are the probable stages of cancerogenesis and have their own quantitative characteristics. MR abnormalities typical for tissue malignancy such as increased mitotic activity, predominance of metaphases over other mitotic stages, and abrupt growth of abnormal mitoses usually outstrip the beginning of infiltrative malignant growth. These data allow one to recommend application of the MR technique to early cancer diagnosis and prognosis of malignancy of pretumourous lesions. In addition, this technique can be used as the criterion for determining tumour histogenesis and evaluating the degree of therapeutic injury to neoplasms.