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Immunocompetence in obesity

R K Chandra, K M Kutty

    Acta Paediatrica Scandinavica
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Obesity in children impairs immune function, particularly cell-mediated responses and bacterial killing. Supplementing iron and zinc improved these immune functions in obese youth.

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    Area of Science:

    • Pediatric immunology
    • Nutritional science
    • Immunodeficiency

    Background:

    • Obesity is a growing global health concern in children and adolescents.
    • Emerging evidence suggests a link between obesity and altered immune system function.
    • Subclinical micronutrient deficiencies may contribute to immune dysregulation in obese youth.

    Purpose of the Study:

    • To investigate cell-mediated immunity and polymorphonuclear leukocyte function in obese children and adolescents.
    • To explore the relationship between obesity, iron, and zinc status, and immune responses.
    • To evaluate the impact of iron and zinc supplementation on immune parameters in this population.

    Main Methods:

    • Assessed in vivo and in vitro cell-mediated immune responses.

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  • Measured intracellular bacterial killing capacity of polymorphonuclear leukocytes.
  • Analyzed serum levels of iron, zinc, immunoglobulins, and complement components.
  • Conducted a 4-week micronutrient (iron and zinc) therapy intervention.

    • Main Results:

    • 38% of obese children and adolescents exhibited impaired cell-mediated immunity and reduced bacterial killing.
    • Obese subjects showed a higher incidence of iron deficiency and lower serum zinc.
    • Immune function improvements were observed after 4 weeks of iron and zinc supplementation.
    • No significant differences in immunoglobulin, complement, T, or B lymphocyte levels were found between groups.

    Conclusions:

    • Subclinical iron and zinc deficiencies are associated with immune impairment in obese children and adolescents.
    • Micronutrient therapy can effectively improve immune responses in this vulnerable group.
    • Addressing nutritional status is crucial for optimizing immune health in pediatric obesity.