[Effect of different doses and administration conditions of propranolol on heart function and hemodynamics]

It was demonstrated in 12 dog experiments with the use of electromagnetic flowmetry and an automatic system of heart function analysis that a single intravenous injection of propranolol in a dose of 0.1 +/- 0.017 mg/kg causes a negative chrono- and inotropic effect and a moderate hypotensive effect in negligible change in the cardiac output. Repeated injections of propranolol in doses of 0.05 mg/kg to a final dose of 0.2 mg/kg at intervals of 5 min (total dose of 0.4 mg/kg) are not attended by increasing inhibition of cardiac function. In systolic and volume load after intravenous injection of propranolol in a dose of up to 0.4 mg/kg it was found that the heart was capable of providing quite adequate hemodynamics. The features of the regulation of cardiac function under these conditions were determined.