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Complement-mediated reactions to diazepam with Cremophor as solvent (Stesolid MR)
British Journal of Anaesthesia
|January 1, 1980
Summary
Adverse reactions to Stesolid MR, Althesin, and propandid may stem from Cremophor, a common solvent. This suggests Cremophor, not the active drug, could be the cause of these complement reactions.
Area of Science:
- Pharmacology
- Immunology
- Drug Safety
Background:
- Adverse drug reactions (ADRs) pose significant challenges in clinical practice.
- Understanding the role of excipients in ADRs is crucial for patient safety.
Observation:
- Two patients experienced adverse reactions attributed to Stesolid MR (diazepam with Cremophor).
- These reactions involved alterations in complement system activity.
Findings:
- A high frequency of adverse reactions was noted with Stesolid MR, Althesin, and propandid.
- The common excipient, Cremophor, is implicated as the likely causative agent for these observed adverse reactions.
Implications:
- The findings suggest that Cremophor, a widely used solvent, may be responsible for complement-mediated adverse reactions.
- This highlights the need for careful evaluation of excipient safety in pharmaceutical formulations.
- Further research into Cremophor-induced hypersensitivity is warranted.