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Updated: Aug 27, 2026

Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
Published on: January 14, 2014
[Effect of acute hypoxic hypoxia on the lung air-blood barrier thickness]
Abstract:
Mean arithmetic and mean harmonic thickness of the lung air-blood barrier (ABB) and its component layers were studied in rats of different age groups normally and after inspiration for 30 min of a gas mixtures of N2 and 11.2% O2 by means of the morphometric analysis of electron microphotographs. Acute hypoxic hypoxia provokes an increase in ABB thickness, more pronounced in younger age groups. The ratio of ABB layers' thickness under hypoxia varied in different age groups. The data obtained suggest age-specific features of the mechanism of arterial hypoxemia development in acute hypoxic hypoxia.
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