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Capillary gas chromatographic studies of cholesterol biosynthesis in rats treated with EGYT-1299
Journal of Chromatography
|April 18, 1980
Abstract:
Cholesterol and desmosterol concentrations were assayed by high-performance capillary gas chromatography. It was established that no toxic desmosterol accumulation occurred either in the serum or liver of rats receiving EGYT-1299 treatment. Desmosterol accumulation induced by triparanol was reduced by the agent at doses ten times lower than Atromid S; consequently its cholesterol lowering effect may be attributed to interference with cholesterol biosynthesis.