[African histoplasmosis]

Area of Science:

• Mycology
• Infectious Diseases
• Clinical Case Studies

Background:

• African histoplasmosis is a serious fungal infection caused by *Histoplasma capsulatum* var. *duboisii*.
• It primarily affects the skin, lymph nodes, and bones in endemic regions of Africa.
• Accurate diagnosis and effective treatment are crucial for patient outcomes.

Observation:

• This report presents two cases of African histoplasmosis.
• Detailed clinical presentations, including skin lesions and lymphadenopathy, were observed.
• Histological examination revealed characteristic granulomatous inflammation with yeast forms.

Findings:

• Mycological cultures confirmed the presence of *Histoplasma capsulatum* var. *duboisii*.
• Specific treatment regimens were administered to both patients.
• Treatment response and patient recovery were monitored.

Implications:

• This case report contributes to the understanding of African histoplasmosis clinical spectrum.
• It highlights the importance of integrating clinical, histological, and mycological data for diagnosis.
• Effective management strategies for African histoplasmosis are essential for public health in affected areas.