[Certain features of the morphology of Hodgkin's disease]

Investigation of lymphogranulomatosis process in 42 patients included histological examinations of chains of lymph nodes with varying duration of their involvement. Lymphogranulomatosis was shown to begin with focal involvement of lymph nodes. The specific focus is initially located in the paracortical zone, then the pathological process extends into the medullary zone and finally into the cortical zone. As early and finally into the cortical zone. As early as the focal lesions occur the cell composition already corresponds to one of histological variants of lymphogranulomatosis (by Lukes' classification). No transition from variants with lymphoid prevalence to those with lymphoid exhaustion in groups of removed lymph nodes from the same patient was observed indicating independent development of each histological type and its stability for a given patient. No correlation between the clinical stage and morphological type of lymphogranulomatosis was established.