15-Hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation

Using human platelets isolated from their plasma, we showed that 15-hydroperoxyu-eicosatetraenoic acid (15-HPETE) inhibits platelet aggregation induced either by arachidonic acid or prostaglandin H2 analog. 15-HPETE does not modify platelet prostaglandin and thromboxane formation from exogenous arachidonic acid but does decrease platelet lipoxygenase activity.