[Morphological and enzymatic changes in chicks treated with antibiotics]

The live, kidney and skeletal muscules of 54 chickens fed experimentally with bacitrazin, gallimycin, oleandomycin, tetracyclin, tylan, chlornitromycin, streptomycin and penicillin, and of 10 control birds were investigated pathomorphologically and histochemically (succinate--and lactate-dehdrogenase and esterase). Parenchymal dystrophy in the epithelial cells of the liver and kidney and areactive necrotic foci amid the parenchyma were assessed. Dystrophic and necrotic changes observed in the muscle fibres of treated birds. Reduced enzyme activity was proven. The studies indicate that the morphological and enzyme changes in the liver, kidney and skeletal muscules of chickens treated with bacitrazin, gallimycin, chlornitromycin and streptomycin are greater than these observed in birds fed with tylan, tetracyclin, olenadomycin and penicillin. It is proven that the morphological and enzyme changes established in healthy chickens fed with prophylactic antibiotic doses are due to the antibiotics applied.