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Related Experiment Videos

Relaxin in human decidua

M Bigazzi, E Nardi, P Bruni

    The Journal of Clinical Endocrinology and Metabolism
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Researchers found human decidua contains a substance with relaxin bioactivities, inhibiting uterine contractions. This discovery opens possibilities for isolating human relaxin (RLX).

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    Area of Science:

    • Reproductive biology
    • Endocrinology
    • Biochemistry

    Background:

    • Human relaxin (RLX) has not been previously purified from human tissues, unlike in pigs and rats.
    • Relaxin is known to possess bioactivities related to reproductive functions.

    Purpose of the Study:

    • To investigate the presence and bioactivity of relaxin in human decidua.
    • To explore the potential for isolating and purifying human relaxin.

    Main Methods:

    • Extraction of substances from human decidua tissue and incubation media.
    • Assay of bioactivities, including inhibition of spontaneous uterine contractions and interpubic ligament elongation.
    • Chromatography using Sephadex G-50 to determine molecular weight.

    Main Results:

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    • Human decidua extracts and incubation media exhibited relaxin bioactivities.
    • The active substance was found in a protein fraction with an approximate molecular weight of 6000 daltons.
    • Yields of relaxin bioactivity ranged from 15 to 33.5 GPU/g of fresh decidua tissue.

    Conclusions:

    • Human decidua contains a substance with relaxin bioactivities.
    • This finding suggests the feasibility of isolating and purifying human relaxin from decidua.
    • Decidua is a potential source for human relaxin extraction and purification.