[Histostructural correlations in the hypothalamo-hypophyseal-renal system during hypokinesia]

The type and level of morphological changes in different components of the hypothalamic-pituitary-renal system were studied in male rats exposed to 3-month hypokinesia. A correlation between rearrangement of the interstitium and epithelium of renal collecting tubules and histophysiological parameters of the antidiuretic hormone production and secretion was established. Morphological manifestations of increased water permeability of collecting tubules recorded on test days 1-10 and 30-60 were seen together with enhanced activity of the hypothalamic supraoptic nucleus. Possible mechanisms involved in changes of the renal water excretory function during hypokinesia are discussed.