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Familial cardiomyopathy--a 15-year follow-up
European Journal of Cardiology
|January 1, 1980
Summary
Familial cardiomyopathy (CMP) shows a high prevalence of pathological echocardiographic changes, even in asymptomatic individuals. Echocardiography is crucial for diagnosing CMP, unlike other non-invasive methods.
Area of Science:
- Cardiology
- Genetics
Background:
- A longitudinal study examined five families with familial cardiomyopathy (CMP) starting in 1961-1962.
- A 15-year follow-up investigated mortality and new family members, adding 50 individuals to the study cohort.
Observation:
- Three of six initially diagnosed young subjects with CMP died during the follow-up period.
- A reinvestigation of four families (39 members) utilized non-invasive clinical examinations, including echocardiography (Echo).
Findings:
- Echocardiography revealed a high incidence (17/39) of suspected or definite CMP-consistent pathological changes, with 11 individuals being asymptomatic.
- Non-Echo non-invasive methods were less effective for diagnosis but confirmed Echo findings in symptomatic patients.
- The study observed a heterogeneous CMP pattern, with both symmetric and asymmetric hypertrophy, suggesting a dominant inheritance pattern.
Implications:
- Echocardiography is essential for identifying familial cardiomyopathy, including in asymptomatic cases.
- Further research is needed to determine the progression of borderline changes in symmetric hypertrophy.
- Findings support a dominant inheritance model for familial cardiomyopathy.
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