[Pharmacokinetic study of 2-(N-benzylamino)adamatane (bemantan) by a gas-liquid chromatographic method]

The pharmacokinetics of bemantan 2-(N-benzylamino)adamantane was studied in rat experiments by gas liquid chromatography after the drug was administered in a single dose per os or intraperitoneally. It has been shown that the drug per os is rapidly absorbed by the blood and enters the viscera, readily penetrates the blood-brain barrier. Intraperitoneal administration of the drug in the form of a starch suspension delays the attainment of the maximum drug blood level. With both routes of administration the drug rapidly disappears from the blood and organs. Small amounts of the unchanged drug are excreted in bound and free forms with urine. Rapid disappearance of the drug from the blood and organs is likely to be accounted for by its intensive metabolism, but the formation of conjugated metabolites and their binding to tissue structures.