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Quantitative Autoradiographic Method for Determination of Regional Rates of Cerebral Protein Synthesis In Vivo
Published on: June 28, 2019
Regional and subcellular localization of cycloprolylglycine in rat brain
S S Boiko1, T A Gudasheva, M V Vichuzhanin
1V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Bulletin of Experimental Biology and Medicine
|December 18, 2010
Abstract:
HPLC analysis showed that endogenous cyclopeptide cycloprolylglycine exhibiting mnemotropic and anxiolytic properties is nonuniformly distributed between brain structures in rats: its contents in the whole brain, cortex, and hippocampus were 29.2±1.6, 38.9±8.0, 126.4±32.4 nmol/g, respectively. Cycloprolylglycine distribution between subcellular fractions of brain neurons is also nonuniform: 60% cyclopeptide appeared in the nuclear fraction.
