Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Vasculitis in children's dermatomyositis (author's transl)]

M Miller, F X Carton

    Annales De Dermatologie Et De Venereologie
    |August 1, 1980
    PubMed
    Summary

    Vascular lesions, unlike in adults, are common in childhood dermatomyositis, affecting various organs. These lesions may stem from immune complex deposits, suggesting a distinct pathogenesis in pediatric cases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Acquired cutaneous osteomatosis. A primary monomelic form].

    Annales de dermatologie et de venereologie·1994
    Same author

    Aging in America.

    Dentistry (American Student Dental Association)·1992
    Same author

    Pneumonia associated with Salmonella choleraesuis infection in swine: 99 cases (1987-1990).

    Journal of the American Veterinary Medical Association·1992
    Same author

    Phase III trial of cyclophosphamide versus cyclophosphamide, doxorubicin, and methotrexate in hormone-refractory prostatic cancer. A Hoosier Oncology Group study.

    Cancer·1992
    Same author

    Usefulness of a CACA repeat polymorphism in genotype assignments in Duchenne/Becker muscular dystrophy.

    American journal of medical genetics·1992
    Same author

    Sadistic and self-defeating personality disorder criteria in a rural clinic sample.

    Journal of clinical psychology·1992

    Area of Science:

    • Pediatric Rheumatology
    • Vascular Pathology
    • Immunology

    Context:

    • Children's dermatomyositis frequently exhibits vascular lesions, unlike the adult form.
    • These lesions involve capillaries, arterioles, and veinlets, manifesting as intimal hyperplasia, endothelial necrosis, and thrombosis.
    • Vascular damage occurs in muscles, skin, and visceral organs, including the digestive tract.

    Purpose:

    • To investigate the characteristics and potential pathogenesis of vascular lesions in childhood dermatomyositis.
    • To differentiate the etiology of pediatric dermatomyositis from adult cases.

    Summary:

    • Vascular lesions in pediatric dermatomyositis are characterized by microangiopathy affecting multiple organ systems.
    • Histological findings include intimal hyperplasia, endothelial necrosis, and thrombus formation, sometimes requiring electron microscopy for detection.
    • Immune complex deposition in vascular walls is hypothesized as a key factor, potentially involving a viral trigger.
    • This immune complex-mediated mechanism (Gell and Coombs Type III hypersensitivity) differentiates it from adult dermatomyositis, which may involve delayed hypersensitivity (Type IV).

    Impact:

    • Understanding these vascular manifestations is crucial for diagnosing and managing childhood dermatomyositis.
    • The proposed immune complex pathogenesis links pediatric dermatomyositis to other systemic autoimmune diseases like SLE and polyarteritis nodosa.
    • This research may lead to targeted therapies for vascular complications in juvenile dermatomyositis.

    Related Experiment Videos