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Related Experiment Videos

Complement activation by iodinated contrast media

K H Hsieh, C M Chuang, S C Li

    Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology
    |June 1, 1980
    PubMed
    Summary
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    Iodinated contrast media (ICM) activate complement pathways in children with congenital heart disease, but this activation does not cause adverse reactions. Complement system components like CH50 and C3 showed decreased activity post-infusion.

    Area of Science:

    • Cardiology
    • Immunology
    • Radiology

    Background:

    • Congenital heart disease (CHD) necessitates diagnostic procedures like angiocardiography.
    • Iodinated contrast media (ICM) are frequently used in these procedures.
    • Potential activation of the complement system by ICM is a concern.

    Purpose of the Study:

    • To investigate the activation of the complement system by ICM in children with CHD.
    • To determine if complement activation correlates with adverse reactions to ICM.

    Main Methods:

    • Studied 25 children with CHD undergoing angiocardiography with 76% Urographin.
    • Measured complement components (CH50, C1q, C3, C4, C3 activator) before and at multiple time points after ICM infusion.

    Main Results:

    Related Experiment Videos

    • Significant decreases in total hemolytic activity (CH50), C3, C3 activator, C1q, and C4 were observed post-infusion.
    • Complement activation occurred via both classic and alternative pathways.
    • No adverse reactions were reported in any of the patients.

    Conclusions:

    • ICM activates both classic and alternative complement pathways in children with CHD.
    • Complement activation by ICM in this context does not appear to cause adverse reactions.