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Updated: Aug 9, 2026
08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
[Anticholinergic drugs in open-angle glaucoma (author's transl)]
Klinische Monatsblatter Fur Augenheilkunde
|January 1, 1980
Summary
Pizotifen is safe for treating open-angle glaucoma patients, even without prior glaucoma treatment. This anticholinergic drug does not increase intraocular pressure or cause complications in untreated glaucoma.
Area of Science:
- Ophthalmology
- Pharmacology
Context:
- Anticholinergic drugs are widely used but their contraindication in open-angle glaucoma remains uncertain.
- Previous studies suggested Pizotifen's safety in treated open-angle glaucoma patients.
Purpose:
- To investigate the influence of Pizotifen on intraocular pressure in untreated open-angle glaucoma.
- To determine the safety of Pizotifen in patients with untreated open-angle glaucoma.
Summary:
- Pizotifen (2.5 mg three times daily) was administered to patients with untreated open-angle glaucoma.
- No significant increase in intraocular pressure or complications were observed.
- Results indicate Pizotifen can be safely used in this patient population.
Impact:
- Pizotifen can be safely prescribed for open-angle glaucoma patients, regardless of prior treatment status.
- This finding addresses uncertainty regarding anticholinergic drug use in glaucoma management.
- Expands therapeutic options for managing open-angle glaucoma.
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