[Metabolism of I131-fibrinogen following intravenous and intraperitoneal administration after thrombin loading and...

After intravenous and intraperitoneal administration of 131I-fibrinogen into rats some of the animals were subjected to thrombin loading and hemorrhage. Dynamics of utilization of the labelled protein was dissimilar under these conditions of fibrinogen administration, but consideration of all the data made the results obtained more informative. Intraperitoneal administration of 131I-fibrinogen caused development of the protective reactions towards foreign proteins; as a result appearance of thrombin-resistance was observed. Content of blood fibrinogen within 24 hrs after thrombin loading and hemorrhage was restored due to intensification of fibrinogen anabolism simultaneously with distinct catabolic transformations. Change in the extra/intravasal ratio was of definite importance in the restoration of fibrinogen content after intraperitoneal administration of the labelled protein.