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Plasma and interstitial fluid volume in extensive skin disease
The Journal of Investigative Dermatology
|February 1, 1981
Summary
Patients with extensive skin disease exhibit fluid shifts from plasma to extracellular spaces. This abnormal fluid distribution is linked to increased microvascular water filtration in the skin.
Area of Science:
- Physiology
- Dermatology
- Fluid Balance
Background:
- Extensive skin disease can alter fluid distribution within the body.
- Understanding plasma and extracellular fluid volume is crucial for managing these conditions.
Purpose of the Study:
- To simultaneously determine plasma volume and extracellular fluid volume in patients with extensive skin disease.
- To investigate the fluid distribution abnormalities in these patients compared to healthy controls.
Main Methods:
- Intravenous bolus injection of 131I-labeled human serum albumin and inulin.
- Simultaneous measurement of plasma volume and extracellular fluid volume.
- Calculation of interstitial fluid volume and plasma volume: interstitial fluid volume ratio.
Main Results:
- Patients showed a statistically significant decrease in plasma volume relative to body weight or surface area.
- Extracellular fluid volume and interstitial fluid volume increased in patients.
- The plasma volume to interstitial fluid volume ratio was significantly lower in patients with extensive skin disease.
Conclusions:
- A fluid shift from plasma to extracellular spaces occurs in extensive skin disease.
- Elevated microvascular water filtration in the skin is a likely mechanism for this abnormal fluid distribution.
- These findings highlight the impact of skin disease on systemic fluid homeostasis.