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'Bis'-fibrinogenaemia

A Pezzoli, E Pascali

Scandinavian Journal of Haematology

|January 1, 1981

Summary

This summary is machine-generated.

A rare double fibrinogen band was discovered in a woman during routine plasma protein analysis. This asymptomatic finding did not impact coagulation function, suggesting a unique fibrinogen variant.

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Area of Science:

Clinical Chemistry
Hematology
Protein Electrophoresis

Background:

Routine plasma protein investigation using agarose gel electrophoresis.
Standard coagulation tests are crucial for assessing hemostasis.
Fibrinogen is a key protein in the coagulation cascade.

Observation:

A 79-year-old woman presented with an unexpected double fibrinogen band during electrophoresis.
The patient had no prior history or clinical signs of bleeding disorders.
Standard coagulation parameters, including thrombin clotting time, were within normal limits.

Findings:

The double fibrinogen band was characterized as an asymptomatic electrophoretic abnormality.
Plasma fibrinogen levels were normal by both functional (thrombin clottable protein) and immunological assays.

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The abnormality was not attributed to medication, liver disease, or a clear genetic inheritance pattern.

Implications:

This case highlights the potential for asymptomatic fibrinogen variants detectable by electrophoresis.
It underscores the importance of correlating electrophoretic findings with functional coagulation tests.
Further investigation may be needed to fully characterize the nature and origin of this fibrinogen anomaly.