Related Experiment Video
Updated: Aug 5, 2026
15:04
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
Modeling drug information for a prescription-oriented knowledge base on drugs
C Milstein1, I de Zegher, A Venot
1Département de Biostatistiques et Informatique Médicale, et IRT-Eclimed, UFR Cochin-Port Royal, Université René Descartes Paris V, Paris, France.
Methods of Information in Medicine
|September 1, 1995
Summary
This study introduces a Drug Knowledge Base (DKB) model for computerized drug prescription systems. It structures drug information for clinical decision support and data integration.
Area of Science:
- Pharmacology
- Health Informatics
- Computer Science
Background:
- Limited theoretical frameworks exist for representing drug knowledge in computerized prescription systems.
- The European OPADE project addressed the need for structured drug information.
- Effective drug therapy decision support requires robust data management.
Purpose of the Study:
- To describe the content and structure of a Drug Knowledge Base (DKB).
- To meet the requirements of clinical decision-support systems in drug therapy.
- To facilitate seamless data transfer from diverse information sources.
Main Methods:
- Defined DKB content based on information requirements across drug usage stages (prescribing, administration, follow-up).
- Classified DKB data items along two dimensions: pharmaco-therapeutic entities and information validity scores.
- Entities include PharmacoTherapeutic Group, Component, Manufactured Preparation, and Presentation.
Main Results:
- A structured Drug Knowledge Base (DKB) model was developed.
- The DKB categorizes information by pharmaco-therapeutic entities and validity levels (international, national, local).
- This model supports decision-support systems and data integration.
Conclusions:
- The developed DKB model provides a theoretical basis for representing drug knowledge.
- It enhances computerized drug-prescription applications and clinical decision-making.
- Facilitates standardized data representation for drug therapy management.
Related Concept Videos
01:26Drug Discovery: Overview
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
01:25Drug Classes and Categories
Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
01:02Prescription, Nonprescription and Orphan Drugs
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
01:20Pharmacokinetic Models: Overview
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
01:26Drug Administration and Therapy Phases: Overview
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
01:28Dosage Regimens: Designs and Approaches
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...