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[Growth hormone: who can benefit from it?]
1Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität, München.
Therapeutische Umschau. Revue Therapeutique
|October 1, 1995
Summary
Recombinant human growth hormone (GH) is widely available. While effective for classic conditions like GH deficiency, its use in other situations requires further controlled studies and specialist supervision.
Area of Science:
- Endocrinology
- Pharmacology
Context:
- Recombinant human growth hormone (GH) is now available in unlimited quantities.
- Established indications include GH deficiency (childhood/adult onset), Turner syndrome, and chronic renal insufficiency.
Purpose:
- To review the established and potential indications for recombinant human GH therapy.
- To emphasize the need for controlled studies in nonclassic applications.
- To highlight the importance of judicious use and specialist supervision.
Summary:
- Classic uses of GH therapy are well-defined.
- Potential nonclassic indications include short stature without GH deficiency, catabolic states, severe burns, and osteoporosis.
- Evidence supporting nonclassic uses is limited, necessitating further controlled research.
Impact:
- Informs clinical practice regarding current and potential GH applications.
- Stresses the need for evidence-based decision-making for novel therapeutic uses.
- Promotes responsible and cost-effective utilization of an expensive medication.