Related Experiment Video

Updated: Aug 19, 2026

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

Hypertrophic osteoarthropathy caused by lipoid pneumonia

C Hugosson1, S Bahabri, A Rifai

  • 1Department of Radiology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Pediatric Radiology
|January 1, 1995
PubMed

Insights

A 5-year-old boy developed hypertrophic osteoarthropathy due to lipoid pneumonia from ghee oil aspiration in infancy. This rare condition highlights a unique cause of chronic lung inflammation and joint pain in children.

Area of Science:

  • Pediatrics
  • Pulmonology
  • Rheumatology

Background:

  • Hypertrophic osteoarthropathy (HOA) is a rare condition characterized by digital clubbing, arthritis, and periostosis.
  • While often associated with malignancy or chronic lung disease, pediatric HOA has diverse etiologies.

Observation:

  • A 5-year-old Saudi boy presented with painful joints and digital clubbing.
  • Radiological imaging confirmed hypertrophic osteoarthropathy.
  • A history of ghee oil aspiration in infancy was noted, leading to chronic lung inflammation.

Findings:

  • The underlying cause of HOA was determined to be lipoid pneumonia secondary to ghee oil aspiration.
  • Lung biopsy confirmed the diagnosis of lipoid pneumonia.
  • This case illustrates a unique etiology for pediatric HOA and lipoid pneumonia.

Implications:

  • Highlights the importance of considering aspiration of foreign substances, like ghee oil, in the differential diagnosis of pediatric HOA.
  • Emphasizes the long-term pulmonary and skeletal consequences of early-life aspiration events.
  • Suggests a need for increased awareness among clinicians regarding non-respiratory causes of chronic lung inflammation and HOA in children.

More Related Videos

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome04:45

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Published on: June 2, 2022

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...