Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Parathyroid hormone-related protein

J M Moseley¹, M T Gillespie

¹St. Vincent's Institute of Medical Research, St. Vincent's Hospital, Fitzroy, Australia.

Critical Reviews in Clinical Laboratory Sciences

|January 1, 1995

Summary

Parathyroid hormone-related protein (PTHrP) is a key factor in humoral hypercalcemia of malignancy (HHM). This review explores PTHrP's dual role in cancer and normal physiology, highlighting its local regulatory functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The effect of gonadal status on body composition and bone mineral density in transfusion-dependent thalassemia.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2013

Same author

Prolonged hypocalcemia following denosumab therapy in metastatic hormone refractory prostate cancer.

Bone·2013

Same author

Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2013

Same author

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes.

Bone·2010

Same author

Communication between ephrinB2 and EphB4 within the osteoblast lineage.

Advances in experimental medicine and biology·2009

Same author

Mechanisms involved in skeletal anabolic therapies.

Annals of the New York Academy of Sciences·2006

Area of Science:

Endocrinology
Molecular Biology
Oncology

Background:

Parathyroid hormone-related protein (PTHrP) is a significant mediator of humoral hypercalcemia of malignancy (HHM).
PTHrP is produced by various cancers, including squamous cell carcinomas, and contributes to hypercalcemia in metastatic and hematological malignancies.
The PTHrP gene is complex, yielding multiple transcripts and protein isoforms regulated by hormones and growth factors.

Purpose of the Study:

To review the current understanding of parathyroid hormone-related protein (PTHrP) molecular properties and actions.
To elucidate the role of PTHrP in both cancer-related hypercalcemia and normal physiological processes.
To highlight the importance of PTHrP's local regulatory functions.

Main Methods:

Review of existing literature on PTHrP.
Analysis of data from radioimmunoassays and tissue localization studies.
Investigation of PTHrP actions in various normal tissues.

Main Results:

PTHrP is produced by a wider range of cancers than previously thought, significantly contributing to malignancy-related hypercalcemia.
PTHrP exhibits diverse physiological roles beyond its hormone-like actions, including roles in fetal development, placental calcium transfer, lactation, smooth muscle relaxation, and epithelial cell growth.
Evidence suggests PTHrP primarily functions as a locally produced regulator or cytokine in normal tissues.

Conclusions:

Understanding PTHrP's role is crucial for managing hypercalcemia of malignancy (HHM).
PTHrP's functions extend beyond endocrine actions, playing vital roles in normal tissue physiology.
Further research into PTHrP's local regulatory activities is essential.

Related Experiment Videos