Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The extracellular calcium receptor

S C Hebert1, E M Brown

  • 1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Current Opinion in Cell Biology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Working with democratically elected councillors: Reflections on research engagement in local government.

Public health in practice (Oxford, England)·2026
Same author

Dietary Intervention Reverses Fatty Liver and Altered Gut Microbiota during Early-Life Undernutrition.

mSystems·2020
Same author

Asymptomatic Intestinal Colonization with Protist <i>Blastocystis</i> Is Strongly Associated with Distinct Microbiome Ecological Patterns.

mSystems·2018
Same author

Patterns of treatment among a cohort of older low-income adults starting new medications for osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2014
Same author

Community adjustment of the moron.

American journal of mental deficiency·2010
Same author

Comparative in vitro Activity of Cefuroxime and its Interactions with Aminoglycoside Antibiotics.

Proceedings of the Royal Society of Medicine·2010
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Extracellular calcium (Ca2+o) acts as a first messenger, regulating cell function via newly identified G-protein-coupled receptors. Mutations in these receptors are linked to calcium disorders, highlighting their role in calcium homeostasis.

Area of Science:

  • Cellular biology
  • Endocrinology
  • Molecular biology

Background:

  • Intracellular calcium's role in cell function is established.
  • Extracellular calcium's (Ca2+o) function is less understood but crucial.
  • Ca2+o acts as a signaling molecule modulating cell activities.

Purpose of the Study:

  • To investigate the role of extracellular calcium in cell function.
  • To identify and characterize Ca2+o-sensing receptors.
  • To understand the implications of these receptors in calcium homeostasis and disease.

Main Methods:

  • Cloning of G-protein-coupled receptors sensitive to Ca2+o from bovine parathyroid and rat kidney/brain.
  • Analysis of receptor mutations in human hypercalcemic and hypocalcemic disorders.

Related Experiment Videos

Main Results:

  • Ca2+o-sensing G-protein-coupled receptors were cloned, confirming Ca2+o as a first messenger.
  • Specific receptor mutations were identified in hypercalcemic and hypocalcemic conditions.
  • The receptor's presence in various tissues suggests broader roles beyond calcium homeostasis.

Conclusions:

  • Extracellular calcium sensing is mediated by specific G-protein-coupled receptors.
  • These receptors are critical for maintaining calcium homeostasis in humans.
  • The discovery opens new avenues for understanding Ca2+o's role in diverse cellular functions.