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Malignant transformation of benign gliomas during interstitial irradiation
D Hellwig1, H D Mennel, B L Bauer
1Department of Neurosurgery, Philipps University Marburg, Federal Republic of Germany.
Acta Neurochirurgica. Supplement
|January 1, 1995
Abstract:
Interstitial curietherapy with 125-Iodine is an effective therapeutic option in the treatment of low grade gliomas. Four cases with astrocytoma grade II are presented, where tumour growth characteristics have changed to anaplasia during interstitial irradiation after a primary period of tumour regression. Anaplastic transformation could be due to a radiation effect or an insufficient therapeutic influence of interstitial irradiation on natural tumour progression of glioma growth due to genetic events.