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Updated: Aug 9, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
Disturbed centromeric meiotic pairing leads to chromosome breaks
B F Chadov1, E V Artyomova, G N Buzykanova
1Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
Abstract:
In Drosophila females an extended deletion of the second autosome pericentric heterochromatin Df(2R) M-S2-10 under heterozygous conditions results in the loss of autosome 2, formation of autosomal compounds and stable acrocentric chromosomes (free arms). The presence of an inversion in the opposite chromosome suppresses the clastogenic effect of the deletion. This effect is presumed to be due to the formation of the conjugational loop in the region of pericentric heterochromatin which subsequently breaks.
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