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Biased representation of immunoglobulin heavy chain variable region subgroups in chronic lymphocytic leukemia
I Hakim1, N Amariglio, F Brok-Simoni
1Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Israel Journal of Medical Sciences
|January 1, 1994
Abstract:
The distribution of three immunoglobulin heavy chain variable region gene subgroups (VH1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the VH5 subgroup was observed relative to its small size.