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[Brain changes in leukemias. Histopathological aspects of choroid plexus involvement]
Arquivos De Neuro-Psiquiatria
|December 1, 1978
Summary
Neoplastic brain infiltration is common in leukemia, often without symptoms. Cerebrospinal fluid cytology is crucial for detecting central nervous system (CNS) leukemia and preventing disease reactivation.
Area of Science:
- Neurology
- Oncology
- Hematology
Context:
- Leukemia frequently involves the central nervous system (CNS).
- Neoplastic infiltration of the brain is a common complication in leukemia patients.
- Hemorrhage is another significant CNS lesion in leukemia, though less frequent than infiltration.
Purpose:
- To investigate the frequency and patterns of neoplastic infiltration in the CNS of leukemia patients.
- To highlight the significance of cerebrospinal fluid (CSF) cytology in managing CNS leukemia.
- To emphasize the role of CNS leukemic foci in disease recurrence.
Summary:
- Neoplastic infiltration of the brain occurred in 70.5% of 38 leukemia cases, surpassing hemorrhage (48.5%).
- Leptomeninges were the most common site of infiltration, followed by the choroid plexus (57.8%) and nervous tissue (50%).
- CNS leukemic infiltration often lacks clinical manifestations, underscoring the need for routine CSF cytology.
Impact:
- Routine CSF cytology is vital for early detection of CNS leukemia.
- Identifying CNS leukemic infiltration aids in preventing disease reactivation during therapy.
- Understanding CNS involvement is critical for effective leukemia treatment protocols.