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Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Selectin ligands

A Varki1

  • 1Glycobiology Program, Cancer Center, University of California, San Diego, La Jolla 92093.

Proceedings of the National Academy of Sciences of the United States of America
|August 2, 1994
PubMed
Summary
This summary is machine-generated.

Selectins mediate key blood cell interactions. This review proposes that specific recognition may involve clustered saccharide patches, clarifying selectin ligand function.

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Area of Science:

  • Cellular Biology
  • Immunology
  • Glycobiology

Background:

  • Selectins are crucial cell adhesion molecules mediating blood cell interactions.
  • The precise nature of biologically relevant ligands for selectins remains a subject of extensive research and debate.

Purpose of the Study:

  • To review and analyze the current understanding of selectin-ligand interactions.
  • To propose a novel hypothesis regarding the specificity of selectin recognition.

Main Methods:

  • Literature review and synthesis of existing data on selectin-ligand interactions.
  • Analysis of diverse opinions and experimental findings in the field.

Main Results:

  • Identified a significant volume of information and diverse viewpoints on selectin ligands.
  • Highlighted the complexity and ongoing discussion surrounding selectin-ligand specificity.

Conclusions:

  • Proposes the hypothesis that specificity in selectin-ligand interactions may involve the recognition of clustered saccharide patches.
  • Suggests a potential mechanism for understanding the functional diversity of selectin-mediated cell adhesion.