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[Endocrine chemotherapy for prostatic cancer]

T Maekawa1, N Kashihara, M Tsujita

  • 1Department of Urology, Osaka City University Medical School.

Hinyokika Kiyo. Acta Urologica Japonica
|June 1, 1994
PubMed
Summary

Combining chlormadinone acetate with UFT (uracil and tegafur) improved non-recurrence and survival rates in prostate cancer patients. This endocrine chemotherapy approach shows promise for improved patient outcomes.

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Area of Science:

  • Oncology
  • Urology

Background:

  • Prostate cancer management often involves endocrine therapy.
  • The efficacy of combination chemotherapy requires further investigation.

Purpose of the Study:

  • To compare the efficacy of chlormadinone acetate alone versus in combination with UFT in treating prostate cancer.
  • To evaluate anti-tumor effects, clinical effects, recurrence rates, and survival rates.

Main Methods:

  • A randomized joint study involving 80 prostate cancer patients.
  • Patients were divided into two groups: chlormadinone acetate alone (Group A) and chlormadinone acetate with UFT (Group B).
  • Exclusion of 10 patients, leaving 70 for analysis across different stages (C and D).

Main Results:

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  • No significant difference in side effects between the two groups.
  • Anti-tumor and clinical effects were comparable between Group A and Group B.
  • Group B demonstrated significantly higher non-recurrence and survival rates compared to Group A.

    • Conclusions:

    • Endocrine chemotherapy combining chlormadinone acetate with UFT shows significant benefits in improving non-recurrence and survival rates for prostate cancer.
    • This combination therapy represents a potentially valuable treatment strategy for advanced prostate cancer.