[Intensive intralymphatic and lymphotropic therapy in children]

Area of Science:

• Biomedical research
• Pediatric critical care
• Pharmacology

Background:

• Critically ill children often experience oxidative stress and endotoxemia.
• Lipid peroxidation is a marker of cellular damage in critical illness.
• Endotoxemia contributes to systemic inflammation and organ dysfunction.

Purpose of the Study:

• To evaluate the efficacy of endolymphatic therapy using antibiotics and antioxidants.
• To assess the impact on lipid peroxidation and endotoxicosis in critically ill children.

Main Methods:

• Endolymphatic infusion of nonenzymatic antioxidants (vitamin E, unithiol) and broad-spectrum antibiotics.
• Comparison with a control group receiving standard care.
• Measurement of free-radical lipid peroxidation activity and endotoxicosis levels.

Main Results:

• Endolymphatic therapy significantly reduced free-radical lipid peroxidation activity.
• The treatment accelerated the detoxification process compared to the control group.
• Observed improvements in biochemical markers of critical illness.

Conclusions:

• Endolymphatic administration of antioxidants and antibiotics is effective in mitigating oxidative stress and endotoxicosis.
• This therapeutic approach offers a potential strategy for managing critically ill pediatric patients.
• Further research is warranted to explore long-term benefits and optimal protocols.