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Related Experiment Videos

Effect of basic fibroblast growth factor on normal tympanic membrane

M Mondain1, A Ryan

  • 1Department of Surgery/Otolaryngology, University of California, San Diego School of Medicine, La Jolla.

American Journal of Otolaryngology
|September 1, 1994
PubMed
Summary

Basic fibroblast growth factor (bFGF) increases blood supply and keratinocyte proliferation in the tympanic membrane. This suggests bFGF may accelerate healing of tympanic membrane perforations.

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Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Basic fibroblast growth factor (bFGF) promotes cell growth and is known to enhance tympanic membrane healing.
  • Understanding bFGF's direct impact on the tympanic membrane is crucial for therapeutic applications.

Purpose of the Study:

  • To investigate the direct effects of basic fibroblast growth factor (bFGF) application on a normal tympanic membrane.
  • To assess bFGF's influence on vascularization and cellular proliferation in the tympanic membrane.

Main Methods:

  • Basic fibroblast growth factor (bFGF) was administered to the tympanic membranes of 10 guinea pigs.
  • Application was via the external auditory canal or middle ear over three days, with contralateral ears serving as controls.
  • Effects were evaluated on day 3 post-application.

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Main Results:

  • bFGF application resulted in a greater cumulative and average area of blood vessels in the tympanic membrane compared to placebo.
  • A significant proliferation of keratinocytes was observed post-bFGF treatment.
  • The number of blood vessels did not change significantly.

Conclusions:

  • bFGF induces vasodilatation in the tympanic membrane, leading to increased blood supply.
  • Enhanced vascularization and keratinocyte proliferation suggest a mechanism for accelerated healing of tympanic membrane perforations.
  • These findings support the potential therapeutic use of bFGF in treating tympanic membrane injuries.