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gp120 neurotoxicity in primary cortical cultures
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Advances in Neuroimmunology
|January 1, 1994
Abstract:
The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in a nitric oxide dependent manner in primary cortical cultures at low picomolar concentrations. gp120 neurotoxicity also requires calcium and glutamate and is blocked by glutamate receptor antagonists. In addition, superoxide anions play a role in gp120 neurotoxicity since superoxide dismutase also attenuates neurotoxicity.