Related Experiment Videos
Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV-1 reverse transcriptase
M A Fisher1, P N Yadav, J Yadav
1Department Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark 07103.
Journal of Molecular Recognition : JMR
|September 1, 1994
Abstract:
An 'active analog' approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase. The preliminary results indicate that the O2, O4', and O5' atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.