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CD44 isoforms during differentiation and development

P Ruiz1, C Schwärzler, U Günthert

  • 1Basel Institute for Immunology, Switzerland.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 1, 1995
PubMed
Summary
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Cell adhesion molecules like CD44 are crucial for early mouse development. Specific CD44 variant isoforms show organized expression patterns, suggesting key roles in embryonic development and hemopoiesis.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Biology

Background:

  • Cell adhesion molecules are essential for embryonic organization.
  • The CD44 family of transmembrane glycoproteins, existing in multiple isoforms, is implicated in development.
  • Isoforms are generated by alternative splicing, altering the extracellular domain.

Purpose of the Study:

  • To investigate the role of CD44 variant isoforms in early mouse development.
  • To understand the expression patterns of CD44 isoforms during embryogenesis and lymphohemopoiesis.

Main Methods:

  • Analysis of CD44 standard and variant isoform expression during mouse development.
  • Investigating alternative splicing mechanisms generating CD44 isoforms.

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Main Results:

  • Standard CD44 is expressed from day 9.5 post coitum in mouse embryos.
  • Variant CD44 isoforms exhibit specialized expression patterns as early as day 6.5 in the egg cylinder.
  • Specific variant isoforms emerge during critical differentiation stages in lymphohemopoiesis.

Conclusions:

  • Highly organized expression of CD44 variant isoforms suggests pivotal roles in cellular interactions.
  • CD44 variant isoforms are likely involved in early development, pattern formation, and hemopoiesis.
  • Further research is needed to isolate specific ligands for CD44 variant regions.