Aggressive histological features of keratoacanthoma

Area of Science:

• Dermatopathology
• Surgical Pathology

Background:

• Keratoacanthomas (KAs) are common skin neoplasms.
• Histological assessment is key for understanding tumor behavior.

Purpose of the Study:

• To evaluate the histological features of keratoacanthomas.
• To correlate histological findings with clinical outcomes.

Main Methods:

• Retrospective analysis of 39 keratoacanthomas from 35 patients.
• Histopathological examination for invasion patterns.

Main Results:

• Six cases demonstrated perineural invasion.
• One case showed vascular invasion.
• Histological aggressiveness was not consistently reflected in clinical presentation.

Conclusions:

• Keratoacanthomas can exhibit concerning histological features, including perineural and vascular invasion.
• Despite aggressive histology, clinical progression may be limited.
• Long-term patient follow-up is essential for managing keratoacanthomas.