[Study on adjuvant effect of Schistosoma japonicum iRNA]

The adjuvant effect of schistosome iRNA on the schistosome antigen was studied. The results by using ELISA showed that the antibody level in mice immunized with S iRNA + SWA was significantly higher than in those only immunized with S iRNA or SWA. After cercariae challenge infection, mice immunized with S iRNA + SWA or S iRNA had higher worm reduction rate. However, there were no significant differences between the two groups of mice in terms of worm reduction rate. These results suggested that the host humoral response can be enhanced by S iRNA and that the host immunity against S. japonicum failed to be enhanced by S iRNA.