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MF59. Design and evaluation of a safe and potent adjuvant for human vaccines
G Ott1, G L Barchfeld, D Chernoff
1Chiron Corporation, Emeryville, California 94608, USA.
Pharmaceutical Biotechnology
|January 1, 1995
Abstract:
MF59 is a safe, practical, and potent adjuvant for use with human vaccines. The formulation is easily manufactured, may be sterilized by filtration, and is both compatible and efficacious with all antigens tested to date. MF59 has been shown to be a potent stimulator of cellular and humoral responses to subunit antigens in both animal models and clinical studies. Toxicology studies in animal models and Phase I-III studies in humans have demonstrated the safety of MF59 with HSV, HIV, and influenza vaccines.