Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell surface molecules in basal cell carcinomas

M Pentel1, K F Helm, M M Maloney

  • 1Division of Dermatology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Actinic keratosis: precancer, squamous cell carcinoma, or marker of field cancerization?

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2009
Same author

Effect of novel filler particles on the mechanical and wear properties of dental composites.

Dental materials : official publication of the Academy of Dental Materials·2001
Same author

Dense inflammation does not mask residual primary basal cell carcinoma during Mohs micrographic surgery.

Journal of the American Academy of Dermatology·2001
Same author

Trichoblastoma or trichoblastic carcinoma?

Journal of the American Academy of Dermatology·2001
Same author

Poromas of the head and neck.

Journal of the American Academy of Dermatology·2001
Same author

Spiny keratoderma.

Cutis·2000
Same journal

A Comprehensive Review of Dermal Fillers and Biostimulators for Neck Rejuvenation.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

Reconstruction of a Defect Involving the Upper Lip, Alar Base, and Medial Cheek.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

Extramammary Paget Disease: A Single-Center, Clinical Analysis.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

Frozen Section Biopsy as a Real-Time Decision-Support Tool in Dermatologic Surgery: A Retrospective Review.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

MSH6-Associated Muir-Torre Syndrome Diagnosed in the Setting of Cutaneous Squamous Cell Carcinoma.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

How We Do It: Selection of Hidradenitis Suppurativa Lesions for Deroofing Based on Surface Contour.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
See all related articles

Cellular adhesion molecules, specifically alpha 2 and beta 1 integrin, are present in basal cell carcinomas (BCCs). However, their expression does not correlate with BCC histological subtypes or invasive potential.

Area of Science:

  • Dermatology
  • Oncology
  • Cell Biology

Background:

  • The factors influencing basal cell carcinoma (BCC) growth patterns and invasiveness remain unclear.
  • Cellular adhesion molecules (CAMs) are implicated in tumor invasion and metastasis in other cancers.
  • Integrins, crucial for cell-stroma interactions, are found on BCCs and may regulate tumor growth.

Purpose of the Study:

  • To compare the expression of specific CAMs in various BCC histological subtypes.
  • Investigated alpha 2 integrin, beta 1 integrin, ICAM-1, VCAM-1, LFA-1a, and E-selectin.

Main Methods:

  • BCC samples were obtained from patients undergoing Mohs surgery.
  • Histological subtypes (nodular, micronodular, mixed, infiltrative, basosquamous) were classified.
  • Avidin-biotin-immunoperoxidase staining was used to detect CAM expression.

Related Experiment Videos

Main Results:

  • BCCs consistently expressed alpha 2 and beta 1 integrin.
  • No significant differences in the quantity or pattern of integrin expression were observed across different BCC histological subtypes.

Conclusions:

  • Integrin expression in BCCs may potentially limit tumor growth through stromal binding.
  • Integrin expression levels do not appear to correlate with the histological patterns observed in basal cell carcinomas.