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Peripheral giant cell granuloma. An immunohistochemical and ultrastructural study
Y R Carvalho1, A M Loyola, R S Gomez
1Department of Oral Pathology, School of Dentistry, State University of São Paulo, Brazil.
Oral Diseases
|March 1, 1995
Summary
Peripheral giant cell granuloma (PGCG) cells are primarily from the mononuclear phagocyte system. Langerhans cells are present in most PGCG lesions, indicating their role in jaw PGCG.
Area of Science:
- Oral pathology
- Immunohistochemistry
- Cell biology
Background:
- Peripheral giant cell granuloma (PGCG) is a reactive lesion.
- Understanding the cellular composition of PGCG is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the cellular origins and characteristics of mononuclear and multinucleated cells in PGCG.
- To determine the presence and type of immune cells within PGCG lesions.
Main Methods:
- Immunohistochemical staining of 40 PGCG tissue samples for various cell markers.
- Transmission electron microscopy analysis of six PGCG cases.
- Analysis included markers such as vimentin, CD68, S-100 protein, and LCA.
Main Results:
- Both mononuclear and multinucleated cells expressed vimentin, alpha I-antichymotrypsin, and CD68.
- S-100 protein-positive dendritic mononuclear cells (Langerhans cells) were found in 67.5% of lesions.
- Ultrastructural analysis revealed phagocytic mononuclear cells and varied multinucleated giant cell morphologies.
Conclusions:
- PGCG of the jaws predominantly comprises cells from the mononuclear phagocyte system.
- Langerhans cells are a significant component in a majority of PGCG lesions.