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Crosslines, fluorophores in the AGE-related cross-linked proteins
K Ienaga1, K Nakamura, T Hochi
1Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co. Ltd, Hyogo, Japan.
Contributions to Nephrology
|January 1, 1995
Abstract:
We can summarize our results as follows: (1) A pair of fluorescent crosslines were isolated from the Maillard reaction mixture; (2) AGE-proteins contained crossline-like structures, and (3) crossline-like immunoreactivities were accumulated in renal tissues of diabetic rats. From these results we concluded that fluorophores in AGE proteins have crossline-like structures and we had the first indication that XLs could be markers for renal disorders.